3x5 Oh, The Guilt
Derek is very upbeat about finalizing his divorce from Addison. He lets her have the Manhattan brownstone and their house in the Hamptons; he just wants to keep his trailer in Seattle. She tries to tell him it wasn't just a one-night stand with Mark, but he's determined to be the bad guy since his adultery involved an actual relationship.
Izzie's happy too. She shows Meredith and George the $8.7 million check -- and promptly spills orange juice all over it! She talks about what she might do with the money -- maybe open a bed and breakfast. They anxiously urge her to deposit it in a bank, and she says she will, right after she cleans out her hospital locker. She later tells Addison she feels guilty about the money.